o-phenyl isopropyl ketone

Base Information

• Chemical Name: o-phenyl isopropyl ketone
• CAS No.: 147531-54-2
• Molecular Formula: C₂₄H₂₆NO₂P
• Molecular Weight: 391.45
• Mol file: 147531-54-2.mol

Synonyms:o-phenyl isopropyl ketone

Chemical Property of o-phenyl isopropyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of o-phenyl isopropyl ketone

There total 5 articles about o-phenyl isopropyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylaminobenzonitrile (17583-40-3) → o-phenyl isopropyl ketone (147531-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) HCl / 1.) THF, Et₂O, 0 deg C, 5 h, 2.) H₂O, room temperature, 0.5 h

2: 1.) EtOH, 3.) K₂CO₃ / 1.) toluene, reflux, overnight, 2.) THF, room temperature, 1 h, 3.) 15 min

With hydrogenchloride; ethanol; potassium carbonate;

DOI:10.1039/P19930002463

Reference yield:

2-methylaminobenzamide (7505-81-9) → o-phenyl isopropyl ketone (147531-54-2)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃ / pyridine

2: 2.) 10 percent HCl / 1.) Et₂O, a.) 0 deg C to r.t., b.) r.t., 5 h, 2.) 0 deg C, 3 h

3: toluene / Heating

4: 2.) K₂CO₃ / 1.) THF, r.t., 1 h, 2.) 15 min

With hydrogenchloride; potassium carbonate; trichlorophosphate; In pyridine; toluene;

DOI:10.1016/S0040-4020(01)90195-4

Reference yield:

2-N-methylaminophenyl isopropyl ketone (32606-05-6) → o-phenyl isopropyl ketone (147531-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: 2.) K₂CO₃ / 1.) THF, r.t., 1 h, 2.) 15 min

With potassium carbonate; In toluene;

DOI:10.1016/S0040-4020(01)90195-4

upstream raw materials:

formaldehyd

2-N-methylaminophenyl isopropyl ketone

chloro-diphenylphosphine

2-methylaminobenzonitrile

Downstream raw materials:

3-isopropyl-1-methyl-1H-indole