1,2,3,4-Tetrahydronaphthalen-1-ylmethanol

Base Information

• Chemical Name: 1,2,3,4-Tetrahydronaphthalen-1-ylmethanol
• CAS No.: 66377-63-7
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.232
• European Community (EC) Number: 865-010-7
• Nikkaji Number: J964.394J
• ChEMBL ID: CHEMBL2041407
• Mol file: 66377-63-7.mol

Synonyms:1,2,3,4-tetrahydronaphthalen-1-ylmethanol;66377-63-7;(1,2,3,4-tetrahydronaphthalen-1-yl)methanol;(S)-1,2,3,4-Tetrahydro-1-naphthalenemethanol;151831-52-6;Tetralin-1-methanol;(R)-(1,2,3,4-Tetrahydro-1-naphthyl)methanol;(S)-(1,2,3,4-Tetrahydro-1-naphthyl)methanol;SCHEMBL1125535;CHEMBL2041407;LBARXHIIOCOWOG-UHFFFAOYSA-N;MFCD32691045;MFCD32691046;AKOS012012498;1,2,3,4-tetrahydronaphthylmethan-1-ol;SY270607;SY270608;CS-0258328;EN300-69779;E86996;(1,2,3,4-tetrahydro naphthalen-1-yl)-methanol;(1,2,3,4-tetrahydro-naphthalen-1-yl)-methanol;Z995212536

Chemical Property of 1,2,3,4-Tetrahydronaphthalen-1-ylmethanol

Chemical Property:

• Boiling Point: 106-109 °C(Press: 1 Torr)
• Density: 1.047±0.06 g/cm3(Predicted)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 162.104465066
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

98% ^*data from raw suppliers

1,2,3,4-tetrahydronaphthalen-1-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(C2=CC=CC=C2C1)CO

Technology Process of 1,2,3,4-Tetrahydronaphthalen-1-ylmethanol

There total 29 articles about 1,2,3,4-Tetrahydronaphthalen-1-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tetralin-1-carboxylic acid (1914-65-4) → (1,2,3,4-tetrahydronaphthalen-4-yl)methanol (66377-63-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield: 91.0%

2-(3-phenyl-propyl)-oxirane (86088-36-0) → (1,2,3,4-tetrahydronaphthalen-4-yl)methanol (66377-63-7) + 5-phenyl-1-pentanal (36884-28-3) + 5-phenyl-1,2-pentanediol (153558-53-3) + 2-chloro-5-phenyl-1-pentanol

Guidance literature:

With tin(IV) chloride; In dichloromethane; 1.) reflux, 4 h, 2.) room temp., 19 h;

DOI:10.1021/jo00163a001

Reference yield: 71.0%

1,2,3,4-tetrahydro-1-naphthalenecarbaldehyde (155566-54-4,18278-24-5) → (1,2,3,4-tetrahydronaphthalen-4-yl)methanol (66377-63-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h;

DOI:10.1021/jm970497w

upstream raw materials:

5-phenylpent-1-ene

2-(3-phenyl-propyl)-oxirane

1,2,3,4-tetrahydro-1-naphthalenecarbaldehyde

1-naphthalene methanol

Downstream raw materials:

naphthalene

3,4-dihydronaphthalene-1(2H)-one

1-Iodomethyl-1,2,3,4-tetrahydro-naphthalene

1-Methylnaphthalene