(S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

Base Information

Chemical Name:(S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
CAS No.:1426686-92-1
Molecular Formula:C₂₃H₂₅ClN₆O₂
Molecular Weight:452.944
Hs Code.:

Synonyms:(S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

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Chemical Property of (S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

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Technology Process of (S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

There total 11 articles about (S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.41%

: 1426687-02-6
(S)-tert-butyl (2-((6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)ethyl)carbamate

: 1426686-92-1
(S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1260907-17-2
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4] benzodiazepin-4-yl]-N-ethylacetamide

: 1426686-92-1
(S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 15 h / -20 - 20 °C

2: potassium carbonate / acetonitrile / 16 h / 80 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With boron tribromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1426686-92-1
(S)-2-(8-(2-aminoethoxy)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 18 h / 140 °C / Inert atmosphere

2.1: toluene; tetrahydrofuran; diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 60 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 18 h / 80 °C / Inert atmosphere

5.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C

6.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

6.2: 1 h / 0 - 20 °C / Inert atmosphere

7.1: acetic acid / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

8.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

9.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

9.2: 18 h / 20 °C / Inert atmosphere

10.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C / Inert atmosphere

11.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 90 °C

12.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C / Inert atmosphere

With tetraphosphorus decasulfide; boron tribromide; sodium carbonate; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;