2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine

Base Information

• Chemical Name: 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine
• CAS No.: 200813-56-5
• Molecular Formula: C₁₆H₂₂N₂O₆
• Molecular Weight: 338.36
• Mol file: 200813-56-5.mol

Synonyms:2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine

Chemical Property of 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine

There total 10 articles about 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-ethoxycarbonylmethyl-1-(4-methylphenylsulfonyl)hydrazine (200813-55-4) → 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine (200813-56-5)

Guidance literature:

With magnesium; at 25 ℃; for 0.5h; Irradiation;

DOI:10.1055/s-1997-1368

Reference yield: 96.0%

C28H33N3O8 (929720-03-6) → 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine (200813-56-5)

Guidance literature:

With methylamine; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2006.12.085

Reference yield: 63.0%

glycolic acid methyl ester (96-35-5) + di-tert-butyl dicarbonate (24424-99-5) + N-benzyloxycarbonyl-hydrazine (5331-43-1) → 2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-methoxycarbonylmethylhydrazine (200813-56-5)

Guidance literature:

Multistep reaction;

DOI:10.1016/j.tetlet.2004.03.063

upstream raw materials:

methanol

2-benzyloxycarbonyl-1-tert-butoxycarbonyl-2-ethoxycarbonylmethyl-1-(4-methylphenylsulfonyl)hydrazine

glycolic acid methyl ester

di-tert-butyl dicarbonate

Refernces

• 1、 Bouillon, Isabelle,Brosse, Nicolas,Vanderesse, Régis,Jamart-Grégoire, Brigitte. "Synthesis of Nα-Z, Nβ-Fmoc or Boc protected α-hydrazinoacids and study of the coupling reaction in solution of Nα-Z-α-hydrazinoesters". . p. 2223 - 2234. Retrieved 2007/10/03.