3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

Base Information

Chemical Name:3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine
CAS No.:1333413-08-3
Molecular Formula:C₅₅H₆₄N₄O₉Si
Molecular Weight:953.22
Hs Code.:

Synonyms:3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

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Chemical Property of 3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

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Technology Process of 3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

There total 1 articles about 3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1120329-65-8
3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-piperazino-2',3'-secouridine

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1333413-08-3
3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.06.087

Reference yield: 83.0%

: 1333413-08-3
3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

: 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

Guidance literature:: With pyridine hydrochloride; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.06.087

Reference yield:

: 1333413-08-3
3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

: 3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-(4-(9-fluorenylmethoxycarbonyl)piperazino)-2',3'-secouridine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine hydrochloride; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: N,N-diisopropylamine tetrazolide / dichloromethane / 20 °C / Inert atmosphere

With N,N-diisopropylamine tetrazolide; pyridine hydrochloride; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.06.087