4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid

Base Information

Chemical Name:4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid
CAS No.:1369962-48-0
Molecular Formula:C₂₂H₂₂N₄O₇S
Molecular Weight:486.505
Hs Code.:

Synonyms:4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid

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Chemical Property of 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid

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Technology Process of 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid

There total 6 articles about 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369963-16-5
tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate

: 1369962-48-0
4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid

Guidance literature:: tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1369962-48-0
4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; di-tert-butyl dicarbonate / tetrahydrofuran / 10 h / 20 °C

1.2: 6 h / 35 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 3102.97 Torr

3.1: pyridine / dichloromethane / 1 h / Cooling with ice

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

5.1: sodium hydroxide; water / ethanol; methanol / 0.5 h / Cooling with ice

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; dmap; di-tert-butyl dicarbonate; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 19756-72-0
tert-butyl 4-nitrobenzoate

: 1369962-48-0
4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 3102.97 Torr

2: pyridine / dichloromethane / 1 h / Cooling with ice

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

4: sodium hydroxide; water / ethanol; methanol / 0.5 h / Cooling with ice

5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;