Technology Process of N2-(4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)phenyl)-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine
There total 7 articles about N2-(4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)phenyl)-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-5-fluoro-N4-(2,2,6,6-tetramethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride; 4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine;
With
toluene-4-sulfonic acid;
In
isopropyl alcohol;
at 70 ℃;
for 168h;
With
sodium hydroxide;
In
water; ethyl acetate;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / ethyl acetate / -30 - -20 °C
1.2: 1.08 h / -20 - -15 °C
2.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere
3.1: sodium hydrogencarbonate / dichloromethane / 20 °C
3.2: Cooling with ice
4.1: trifluoromethylsulfonic anhydride; trimethylsilylazide / acetonitrile / -5 °C / Inert atmosphere
5.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol; water / 1551.49 Torr
6.1: toluene-4-sulfonic acid / isopropyl alcohol / 168 h / 70 °C
6.2: 20 °C
With
trifluoromethylsulfonic anhydride; trimethylsilylazide; sulfuric acid; hydrogen; sodium hydrogencarbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; tricyclohexylphosphine;
palladium 10% on activated carbon; palladium diacetate;
In
ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / dichloromethane / 20 °C
2.2: Cooling with ice
3.1: trifluoromethylsulfonic anhydride; trimethylsilylazide / acetonitrile / -5 °C / Inert atmosphere
4.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol; water / 1551.49 Torr
5.1: toluene-4-sulfonic acid / isopropyl alcohol / 168 h / 70 °C
5.2: 20 °C
With
trifluoromethylsulfonic anhydride; trimethylsilylazide; hydrogen; sodium hydrogencarbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; tricyclohexylphosphine;
palladium 10% on activated carbon; palladium diacetate;
In
ethanol; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile;
