2-(Aminomethyl)-1,3-dioxolane

Base Information

Chemical Name:2-(Aminomethyl)-1,3-dioxolane
CAS No.:4388-97-0
Molecular Formula:C4H9NO2
Molecular Weight:103.121
Hs Code.:2932999099
European Community (EC) Number:672-753-9
DSSTox Substance ID:DTXSID70445904
Nikkaji Number:J254.878J
Wikidata:Q72439470
Mol file:4388-97-0.mol

Synonyms:2-(Aminomethyl)-1,3-dioxolane;4388-97-0;(1,3-Dioxolan-2-yl)methanamine;1,3-dioxolan-2-ylmethanamine;1,3-dioxolane-2-methanamine;dioxolane-methanamine;starbld0018945;2-aminomethyl-1,3-dioxolan;SCHEMBL94099;1,3-Dioxolan-2 ylmethylamine;DTXSID70445904;(1,3-Dioxolan-2-ylmethyl)amine;QXXRLUXAOFVOTE-UHFFFAOYSA-N;CS-D0489;1-(1,3-dioxolan-2-yl)methanamine;1-(1,3-dioxolan-2-yl)methylamine;C-[1,3]dioxolan-2-yl-methylamine;N-(1,3-Dioxolan-2-ylmethyl)amine;MFCD00142862;AKOS006229588;BS-22758;A1179;FT-0735326;F50673;EN300-6960162

Suppliers and Price of 2-(Aminomethyl)-1,3-dioxolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(Aminomethyl)-1,3-dioxolane
100mg
$ 60.00

TCI Chemical
2-(Aminomethyl)-1,3-dioxolane >98.0%(GC)(T)
5g
$ 472.00

TCI Chemical
2-(Aminomethyl)-1,3-dioxolane >98.0%(GC)(T)
1g
$ 144.00

Frontier Specialty Chemicals
2-(Aminomethyl)-1,3-dioxolane
5g
$ 140.00

Frontier Specialty Chemicals
2-(Aminomethyl)-1,3-dioxolane
1g
$ 35.00

American Custom Chemicals Corporation
2-(AMINOMETHYL)-13-DIOXOLANE 95.00%
5G
$ 1149.32

American Custom Chemicals Corporation
2-(AMINOMETHYL)-13-DIOXOLANE 95.00%
1G
$ 715.65

AK Scientific
(1,3-Dioxolan-2-yl)methanamine
5g
$ 557.00

Total 37 raw suppliers

Chemical Property of 2-(Aminomethyl)-1,3-dioxolane

Chemical Property:

Refractive Index:1.4460-1.4490
Boiling Point:154.449 °C at 760 mmHg
PKA:9.77±0.29(Predicted)
Flash Point:47.693 °C
PSA：44.48000
Density:1.079 g/cm³
LogP:0.01830
XLogP3:-1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:103.063328530
Heavy Atom Count:7
Complexity:51.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Aminomethyl)-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 11-36/37/38
Safety Statements: 16-26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC(O1)CN
Uses 2-(Aminomethyl)-1,3-dioxolane is a useful reactant for the preparation of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors for improved membrane permeability.

Technology Process of 2-(Aminomethyl)-1,3-dioxolane

There total 1 articles about 2-(Aminomethyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22483-09-6
2,2-dimethoxyethylamine

: 4388-97-0
(1,3-dioxolan-2-yl)methanamine

Guidance literature:: With sodium hydroxide; In ethylene glycol; benzene;

Reference yield: 88.0%

: 2845-89-8
1-chloro-3-methoxy-benzene

: 4388-97-0
(1,3-dioxolan-2-yl)methanamine

: 1538625-24-9
N-((1,3-dioxolan-2-yl)methyl)-3-methoxyaniline

Guidance literature:: With (2,2′-bis(biphenylphosphino)-1,1′-binaphthalene)Ni(η2-NC-Ph); sodium t-butanolate; In toluene; at 50 ℃; for 24h; Inert atmosphere; Glovebox;
DOI:10.1021/ja411911s

Reference yield: 70.0%

: 553-90-2
Dimethyl oxalate

: 727382-68-5
4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester

: 4388-97-0
(1,3-dioxolan-2-yl)methanamine

: 1246616-85-2
C₂₁H₂₃NO₈

Guidance literature:: Dimethyl oxalate; 4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester; With sodium methylate; In methanol; at 20 ℃; for 2h;

(1,3-dioxolan-2-yl)methanamine; With acetic acid; In 1,3-dimethyl-2-imidazolidinone; methanol; at 20 ℃; for 38h;