D,L-phenacetylserine methyl ester

Base Information

Chemical Name:D,L-phenacetylserine methyl ester
CAS No.:65415-04-5
Molecular Formula:C₁₂H₁₅NO₄
Molecular Weight:237.255
Hs Code.:

Synonyms:D,L-phenacetylserine methyl ester

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Chemical Property of D,L-phenacetylserine methyl ester

Chemical Property:

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Technology Process of D,L-phenacetylserine methyl ester

There total 4 articles about D,L-phenacetylserine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 536-74-3
phenylacetylene

: 65415-04-5,65414-91-7
methyl (2-phenylacetyl)-L-serinate

Guidance literature:: With potassium hexafluorophosphate; 4-methylpyridine-1-oxide; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); potassium carbonate; In water; 1,2-dichloro-ethane; at 37 ℃; for 24h; chemoselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.9b01993

Reference yield: 75.0%

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 103-80-0
phenylacetyl chloride

: 65415-04-5,65414-91-7
methyl (2-phenylacetyl)-L-serinate

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 3h; pH=8 - 9;
DOI:10.1016/j.bmc.2007.05.013

Reference yield:

: 67-56-1
methanol

: 103-82-2
phenylacetic acid

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

: 65415-04-5,65414-91-7
methyl (2-phenylacetyl)-L-serinate

Guidance literature:: N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

With piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; for 0.5h;

methanol; phenylacetic acid; Further stages;
DOI:10.1021/acs.jmedchem.8b01259