5-amino-1-benzofuran-2-carboxylic acid

Base Information

• Chemical Name: 5-amino-1-benzofuran-2-carboxylic acid
• CAS No.: 42933-44-8
• Molecular Formula: C9H7 N O3
• Molecular Weight: 177.159
• Hs Code.: 2932999099
• Mol file: 42933-44-8.mol

Synonyms:5-amino-1-benzofuran-2-carboxylic acid

Chemical Property of 5-amino-1-benzofuran-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >300oC
• Refractive Index: 1.714
• Boiling Point: 406.222oC at 760 mmHg
• PKA: 2.69±0.30(Predicted)
• Flash Point: 199.476oC
• PSA: 76.46000
• Density: 1.462g/cm3
• LogP: 2.29440
• Storage Temp.: 2-8°C

Purity/Quality:

5-Amino-1-benzofuran-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-amino-1-benzofuran-2-carboxylic acid

There total 1 articles about 5-amino-1-benzofuran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-nitrobenzofuran-2-carboxylic acid (10242-12-3) → 5-aminobenzofurane-2-carboxylic acid (42933-44-8)

Guidance literature:

With ammonium sulfide;

Reference yield: 74.8%

methanol (67-56-1) + 5-aminobenzofurane-2-carboxylic acid (42933-44-8) → 5-aminobenzofuran-2-carboxylic acid methyl ester (1646-29-3)

Guidance literature:

With hydrogenchloride; In methanol; for 20h; Reflux;

Reference yield:

5-aminobenzofurane-2-carboxylic acid (42933-44-8) → vilazodone (163521-12-8)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogenchloride / 20 h / Reflux

2: sodium acetate / water / 1 h / Reflux

3: sodium hydrogencarbonate; potassium iodide / N,N-dimethyl acetamide / 28 h / 75 °C

4: ammonium chloride / N,N-dimethyl acetamide / 7 h / 100 °C

5: 5%-palladium/activated carbon; hydrogen / methanol / 2 h / 15 - 30 °C / 1125.11 Torr

6: ammonia / methanol / 20 h / 20 °C

With hydrogenchloride; 5%-palladium/activated carbon; ammonia; hydrogen; sodium acetate; sodium hydrogencarbonate; ammonium chloride; potassium iodide; In methanol; N,N-dimethyl acetamide; water;

upstream raw materials:

5-nitrobenzofuran-2-carboxylic acid

Downstream raw materials:

5-aminobenzofuran-2-carboxylic acid methyl ester

vilazodone