1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate
CAS No.:645378-55-8
Molecular Formula:C₃₀H₃₅F₇N₂O₃
Molecular Weight:604.608
Hs Code.:

Synonyms:1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

There total 1 articles about 1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 645378-25-2
4-[2-carboxy-1-(4-fluoro-phenyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

: 488098-44-8
α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine

: 645378-55-8
1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

Guidance literature:: 4-[2-carboxy-1-(4-fluoro-phenyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 0.5h;

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

: 645378-55-8
1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

: N-{1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethy}-3-(4-fluorophenyl)-3-(4-piperidinyl) propionamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 645378-55-8
1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

: 74-88-4
methyl iodide

: 645378-56-9
1,1-dimethylethyl-4-[3-[{1-[3, 5-bis(trifluoromethyl)phenyl]-1-methylethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

Guidance literature:: 1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate; With sodium t-butanolate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

methyl iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃;