α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine

Base Information

• Chemical Name: α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine
• CAS No.: 488098-44-8
• Molecular Formula: C₁₁H₁₁F₆N
• Molecular Weight: 271.205
• Mol file: 488098-44-8.mol

Synonyms:α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine

Chemical Property of α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine

There total 2 articles about α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine (488098-44-8)

Guidance literature:

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 90 ℃;

With hydrogenchloride; In diethyl ether; at 20 ℃;

DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate (334477-48-4) → α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine (488098-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. LiOH / tetrahydrofuran; methanol / 20 °C

2.1: (PhO)2PON₃; Et₃N / toluene / 90 °C

2.2: HCl / diethyl ether / 20 °C

With lithium hydroxide; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; methanol; toluene;

DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

4-[2-carboxy-1-(4-fluoro-phenyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester (645378-25-2) + α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine (488098-44-8) → 1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate (645378-55-8)

Guidance literature:

4-[2-carboxy-1-(4-fluoro-phenyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 0.5h;

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine; In DMF (N,N-dimethyl-formamide); at 20 ℃;

upstream raw materials:

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate

Downstream raw materials:

1,1-dimethylethyl-4-[3-({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate

Refernces