1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

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Chemical Name:1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one
CAS No.:543745-12-6
Molecular Formula:C₂₇H₁₆F₄N₄O₂
Molecular Weight:504.443
Hs Code.:

Synonyms:1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

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Chemical Property of 1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

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Technology Process of 1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

There total 11 articles about 1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 543745-11-5
1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

: 40138-16-7
2-formylbenzene boronic acid

: 543745-12-6
1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2006.02.069

Reference yield:

: 385425-15-0
1-(2-oxopiperidin-1-yl)-4-iodobenzene

: 543745-12-6
1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / CHCl₃ / Heating

2.1: 140 °C

3.1: DMAP / CH₂Cl₂

3.2: aq. HCl / diethyl ether

4.1: methanol

5.1: 85 percent / (Ph₃P)4Pd; K₃PO₄ / dioxane

With dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; In 1,4-dioxane; methanol; dichloromethane; chloroform; 5.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.069

Reference yield:

: 5-bromo-pentanoic acid-(4-iodophenyl)amide

: 543745-12-6
1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butoxide

2.1: phosphorus pentachloride / CHCl₃ / Heating

3.1: 140 °C

4.1: DMAP / CH₂Cl₂

4.2: aq. HCl / diethyl ether

5.1: methanol

6.1: 85 percent / (Ph₃P)4Pd; K₃PO₄ / dioxane

With dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; potassium tert-butylate; In 1,4-dioxane; methanol; dichloromethane; chloroform; 6.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.069