2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Base Information

Chemical Name:2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one
CAS No.:1345014-58-5
Molecular Formula:C₂₀H₁₈N₄O
Molecular Weight:330.389
Hs Code.:

Synonyms:2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one

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Chemical Property of 2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one

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Technology Process of 2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one

There total 8 articles about 2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 3731-53-1
4-(aminomethyl)pyridine

: 1345014-05-2
tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

: 1345014-58-5
2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: In tetrahydrofuran; ethanol; at 160 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.tetlet.2013.06.016

Reference yield:

: C₂₅H₂₆N₄O₃

: 1345014-58-5
2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2013.06.016

Reference yield:

: 1345013-92-4
tert-butyl 3-[bis(methylthio)methylene]-2,4-dioxopiperidine-1-carboxylate

: 1345014-58-5
2-phenyl-4-[(pyridin-4-ylmethyl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 2 h / 25 °C

2: ammonium acetate; acetic acid / dimethyl sulfoxide; tetrahydrofuran / 2 h / 90 °C

3: 3-chloro-benzenecarboperoxoic acid / 2 h / 5 - 25 °C

4: tetrahydrofuran; ethanol / 0.5 h / 160 °C / Microwave irradiation

With potassium tert-butylate; ammonium acetate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2013.06.016