1-(3-ethoxyphenyl)-N-methylmethanimine

Base Information

• Chemical Name: 1-(3-ethoxyphenyl)-N-methylmethanimine
• CAS No.: 16928-31-7
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 16928-31-7.mol

Synonyms:1-(3-ethoxyphenyl)-N-methylmethanimine

Chemical Property of 1-(3-ethoxyphenyl)-N-methylmethanimine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-ethoxyphenyl)-N-methylmethanimine

There total 2 articles about 1-(3-ethoxyphenyl)-N-methylmethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethoxybenzaldehyde (22924-15-8) + methylamine (74-89-5) → 1-(3-ethoxyphenyl)-N-methylmethanimine (16928-31-7)

Guidance literature:

analog der Verbindung 3-Methoxy-benzaldehyd-methylimin;

DOI:10.1021/ja01199a061

Reference yield:

3-ethoxybenzaldehyde (22924-15-8) + methylamine hydrochloride (593-51-1) → 1-(3-ethoxyphenyl)-N-methylmethanimine (16928-31-7)

Guidance literature:

With magnesium sulfate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/jacs.0c04558

Reference yield: 87.0%

1-(3-ethoxyphenyl)-N-methylmethanimine (16928-31-7) → (1R,2R)-1,2-bis(3-ethoxyphenyl)-N1,N2-dimethylethane-1,2-diamine

Guidance literature:

1-(3-ethoxyphenyl)-N-methylmethanimine; With (5R,5'R)-4,4,4',4'-tetrakis(2,5-dimethylphenyl)-5,5'-diphenyl-2,2'-bi(1,3,2-dioxaborolane); In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; enantioselective reaction;

DOI:10.1021/jacs.0c04558

upstream raw materials:

3-ethoxybenzaldehyde

methylamine

methylamine hydrochloride

Downstream raw materials:

C₁₈H₂₁NO₂

C₁₈H₂₃NO₂

C₁₈H₂₁NO

C₁₈H₂₁NO

Refernces

• 1、 Pechulis, Anthony D.,Beck, James P.,Curry, Matt A.,Wolf, Mark A.,Harms, Arthur E.,Xi, Ning,Opalka, Chet,Sweet, Mark P.,Yang, Zhicai,Vellekoop, A. Samuel,Klos, Andrew M.,Crocker, Peter J.,Hassler, Carla,Laws, Mia,Kitchen, Douglas B.,Smith, Mark A.,Olson, Richard E.,Liu, Shuang,Molino, Bruce F.. "4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors". . p. 7219 - 7222. Retrieved 2013/01/15.