α-folate-NHS

Base Information

• Chemical Name: α-folate-NHS
• CAS No.: 544429-89-2
• Molecular Formula: C₂₃H₂₂N₈O₈
• Molecular Weight: 538.476
• Mol file: 544429-89-2.mol

Synonyms:α-folate-NHS

Chemical Property of α-folate-NHS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of α-folate-NHS

There total 5 articles about α-folate-NHS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + folate (59-30-3) → C23H22N8O8 (544429-89-2)

Guidance literature:

With carbodiimide reagent; In dimethyl sulfoxide; at 28 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c6ra01482h

Reference yield:

folic acid (59-30-3) + 1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) → α-folate-NHS (544429-89-2) + folic acid, N-hydroxysuccinimide ester (153445-05-7)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + folate (59-30-3) → α-folate-NHS (544429-89-2) + folic acid, N-hydroxysuccinimide ester (153445-05-7)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃; for 12h; Darkness;

DOI:10.1002/cplu.201402342

upstream raw materials:

folic acid

1-hydroxy-pyrrolidine-2,5-dione

folate