(S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate

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Chemical Name:(S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate
CAS No.:1092807-31-2
Molecular Formula:BF₄*C₂₄H₂₂N₃O
Molecular Weight:455.263
Hs Code.:

Synonyms:(S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate

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Chemical Property of (S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate

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Technology Process of (S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate

There total 9 articles about (S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1005209-71-1
(S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate

: 1092807-31-2
(S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate

Guidance literature:: With methanol; trimethylsilyl bromide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo902018j

Reference yield:

: 1005209-74-4
(5S)-5-(diphenyl)(trimethylsilanyloxy)methyl-pyrrolidin-2-one

: 1092807-31-2
(S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 15 h / 20 °C / Inert atmosphere; Schlenk technique

1.2: 20 °C / Inert atmosphere; Schlenk technique

2.1: tetrafluoroboric acid diethyl ether / dichloromethane / 1 h / 40 °C / Inert atmosphere; Schlenk technique

With tetrafluoroboric acid diethyl ether; In dichloromethane;
DOI:10.1055/s-0037-1611786

Reference yield:

: 98-79-3
L-Pyroglutamic acid

: 1092807-31-2
(S)-5-[hydroxy(diphenyl)methyl]-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c]-1,2,4-triazol-2-ium tetrafluoroborate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 4 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: iodine; magnesium / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere; Schlenk technique; Reflux

2.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: 2,6-dimethylpyridine / dichloromethane / 0.08 h / 0 °C / Inert atmosphere; Schlenk technique

3.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

4.1: dichloromethane / 15 h / 20 °C / Inert atmosphere; Schlenk technique

4.2: 20 °C / Inert atmosphere; Schlenk technique

5.1: tetrafluoroboric acid diethyl ether / dichloromethane / 1 h / 40 °C / Inert atmosphere; Schlenk technique

With 2,6-dimethylpyridine; tetrafluoroboric acid diethyl ether; thionyl chloride; iodine; magnesium; In tetrahydrofuran; dichloromethane; 2.1: |Grignard Reaction / 2.2: |Grignard Reaction;
DOI:10.1055/s-0037-1611786