(5S)-5-[diphenyl[(triMethylsilyl)oxy]Methyl]-2-Pyrrolidinone

Base Information

Chemical Name:(5S)-5-[diphenyl[(triMethylsilyl)oxy]Methyl]-2-Pyrrolidinone
CAS No.:1005209-74-4
Molecular Formula:C20H25NO2Si
Molecular Weight:339.51
Hs Code.:
Mol file:1005209-74-4.mol

Synonyms:(5S)-5-[diphenyl[(triMethylsilyl)oxy]Methyl]-2-Pyrrolidinone

Suppliers and Price of (5S)-5-[diphenyl[(triMethylsilyl)oxy]Methyl]-2-Pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (5S)-5-[diphenyl[(triMethylsilyl)oxy]Methyl]-2-Pyrrolidinone

Chemical Property:

Purity/Quality:: >95%,>98%e.e. ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (5S)-5-[diphenyl[(triMethylsilyl)oxy]Methyl]-2-Pyrrolidinone

There total 4 articles about (5S)-5-[diphenyl[(triMethylsilyl)oxy]Methyl]-2-Pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: 149561-81-9
(-)-(S)-5-(Hydroxydiphenylmethyl)pyrrolidin-2-one

: 1005209-74-4
(5S)-5-(diphenyl)(trimethylsilanyloxy)methyl-pyrrolidin-2-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2008.05.017

Reference yield: 96.0%

: 75-77-4
chloro-trimethyl-silane

: 149561-81-9
(-)-(S)-5-(Hydroxydiphenylmethyl)pyrrolidin-2-one

: 1005209-74-4
(5S)-5-(diphenyl)(trimethylsilanyloxy)methyl-pyrrolidin-2-one

Guidance literature:: (-)-(S)-5-(Hydroxydiphenylmethyl)pyrrolidin-2-one; With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere; Schlenk technique;

chloro-trimethyl-silane; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere; Schlenk technique;
DOI:10.1039/d0ob02017f

Reference yield:

: 98-79-3
L-Pyroglutamic acid

: 1005209-74-4
(5S)-5-(diphenyl)(trimethylsilanyloxy)methyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 4 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: iodine; magnesium / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere; Schlenk technique; Reflux

2.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: 2,6-dimethylpyridine / dichloromethane / 0.08 h / 0 °C / Inert atmosphere; Schlenk technique

3.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

With 2,6-dimethylpyridine; thionyl chloride; iodine; magnesium; In tetrahydrofuran; dichloromethane; 2.1: |Grignard Reaction / 2.2: |Grignard Reaction;
DOI:10.1055/s-0037-1611786