(S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate

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Chemical Name:(S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate
CAS No.:1005209-71-1
Molecular Formula:BF₄*C₂₇H₃₀N₃OSi
Molecular Weight:527.445
Hs Code.:

Synonyms:(S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate

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Chemical Property of (S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate

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Technology Process of (S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate

There total 4 articles about (S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1005209-74-4
(5S)-5-(diphenyl)(trimethylsilanyloxy)methyl-pyrrolidin-2-one

: 420-37-1
trimethoxonium tetrafluoroborate

: 100-63-0
phenylhydrazine

: 1005209-71-1
(S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate

Guidance literature:: (5S)-5-(diphenyl)(trimethylsilanyloxy)methyl-pyrrolidin-2-one; trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃;

phenylhydrazine; In dichloromethane; at 20 ℃;

With trimethyl orthoformate; at 80 ℃; Further stages.;
DOI:10.1016/j.tetasy.2008.05.017

Reference yield:

: 98-79-3
L-Pyroglutamic acid

: 1005209-71-1
(S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 4 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: iodine; magnesium / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere; Schlenk technique; Reflux

2.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: 2,6-dimethylpyridine / dichloromethane / 0.08 h / 0 °C / Inert atmosphere; Schlenk technique

3.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

4.1: dichloromethane / 15 h / 20 °C / Inert atmosphere; Schlenk technique

4.2: 20 °C / Inert atmosphere; Schlenk technique

With 2,6-dimethylpyridine; thionyl chloride; iodine; magnesium; In tetrahydrofuran; dichloromethane; 2.1: |Grignard Reaction / 2.2: |Grignard Reaction;
DOI:10.1055/s-0037-1611786

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 1005209-71-1
(S)-5-(diphenyl-trimethylsilanyloxy-methyl)-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-4-ium tetrafluoroborate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / tetrahydrofuran / 3.5 h / 0 °C / Inert atmosphere; Schlenk technique; Reflux

1.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: 2,6-dimethylpyridine / dichloromethane / 0.08 h / 0 °C / Inert atmosphere; Schlenk technique

2.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: dichloromethane / 15 h / 20 °C / Inert atmosphere; Schlenk technique

3.2: 20 °C / Inert atmosphere; Schlenk technique

With 2,6-dimethylpyridine; iodine; magnesium; In tetrahydrofuran; dichloromethane; 1.1: |Grignard Reaction / 1.2: |Grignard Reaction;
DOI:10.1055/s-0037-1611786