methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate

Base Information

• Chemical Name: methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate
• CAS No.: 753454-08-9
• Molecular Formula: C₂₁H₂₂O₆
• Molecular Weight: 370.402
• Mol file: 753454-08-9.mol

Synonyms:methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate

Chemical Property of methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate

There total 4 articles about methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methanol (67-56-1) + 2-(4-methoxy-phenacyl)-4-(4-methoxy-phenyl)-4-oxo-butyric acid (90655-33-7) → methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate (753454-08-9)

Guidance literature:

With sulfuric acid;

DOI:10.1515/HC.2003.9.6.599

Reference yield: 66.0%

2,2-bis-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-malonic acid dimethyl ester (485819-17-8) → methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate (753454-08-9)

Guidance literature:

With water; dimethyl sulfoxide; sodium chloride; at 130 - 150 ℃; for 2.5h;

DOI:10.1515/HC.2003.9.6.599

Reference yield: 63.0%

4-methoxybenzoic acid (100-09-4) + tert-butyl((1-(4-methoxyphenyl)vinyl)oxy)dimethylsilane (80676-78-4) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 4-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-2-oxoethyl)-4-oxobutanoate (753454-08-9)

Guidance literature:

With 2,6-dimethylpyridine; fac-tris(2-phenylpyridinato-N,C₂')iridium(III); dimethyl dicarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1002/chem.201701589

upstream raw materials:

methanol

2-(4-methoxy-phenacyl)-4-(4-methoxy-phenyl)-4-oxo-butyric acid

2,2-bis-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-malonic acid dimethyl ester

2-cyano-4-(4-methoxy-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-4-oxo-butyric acid ethyl ester

Downstream raw materials:

2,6-bis-(4-methoxy-phenyl)-4H-pyran-4-carboxylic acid methyl ester