Piperidine-4-carbohydrazide

Base Information

• Chemical Name: Piperidine-4-carbohydrazide
• CAS No.: 42596-58-7
• Molecular Formula: C6H13 N3 O
• Molecular Weight: 143.189
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00332439
• Nikkaji Number: J597.147K
• Wikidata: Q82097062
• ChEMBL ID: CHEMBL122482
• Mol file: 42596-58-7.mol

Synonyms:piperidine-4-carbohydrazide;42596-58-7;4-Piperidinecarboxylic acid hydrazide;4-Piperidinecarboxylic acid, hydrazide;Piperidine-4-carboxylic acid hydrazide;Piperid CON2;4-Piperidinecarbohydrazide #;CHEMBL122482;SCHEMBL18394618;DTXSID00332439;MFCD01245724;STK089915;AKOS005174211;SB41391;LS-04192;CS-0204941;EN300-864262

Chemical Property of Piperidine-4-carbohydrazide

Chemical Property:

• PSA: 67.15000
• LogP: 0.39590
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 143.105862047
• Heavy Atom Count: 10
• Complexity: 120

Purity/Quality:

98%min ^*data from raw suppliers

Piperidine-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C(=O)NN

Technology Process of Piperidine-4-carbohydrazide

There total 5 articles about Piperidine-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate (187834-88-4) → piperidine-4-carboxylic acid hydrazide (42596-58-7)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1016/j.tube.2021.102100

Reference yield: 71.0%

4-carbethoxypiperidine (1126-09-6) → piperidine-4-carboxylic acid hydrazide (42596-58-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 10.25h; Cooling with ice; Reflux;

Reference yield: 24.0%

isonipecotic acid methyl ester (2971-79-1) → piperidine-4-carboxylic acid hydrazide (42596-58-7)

Guidance literature:

With hydrazine hydrate; In methanol; at 90 ℃;

DOI:10.1002/cmdc.201700440

upstream raw materials:

4-carbethoxypiperidine

isoniazid

methyl piperidine-4-carboxylate hydrochloride

isonipecotic acid methyl ester

Downstream raw materials:

2,3-dimethoxy-6-[(piperidine-4-carbonylhydrazono)-methyl]-benzoic acid

piperidine-4-carboxylic acid vanillylidenehydrazide

4-carboxamidopiperidine