10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III

Base Information

Chemical Name:10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III
CAS No.:325735-55-5
Molecular Formula:C₄₉H₇₁NO₁₁SeSi₂
Molecular Weight:985.234
Hs Code.:

Synonyms:10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III

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Chemical Property of 10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III

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Technology Process of 10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III

There total 10 articles about 10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 51694-22-5
ortho-nitrophenyl selenocyanate

: 325735-53-3
10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III

: 325735-55-5
10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: With tributylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.3987/COM-00-9051

Reference yield:

: 204764-74-9
10-deacetoxy-10-hydroxypropyl-7-O-triethylsilylbaccatin III

: 325735-55-5
10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 6 steps

1.1: 73 percent / n-Bu₃P / tetrahydrofuran / 2 h / 20 °C

2.1: 81 percent / m-CPBA / tetrahydrofuran / 3 h / 20 °C

3.1: imidazole / dimethylformamide / 2 h / 20 °C

4.1: OsO₄; NMO / tetrahydrofuran; H₂O / 15 h / 20 °C

4.2: NaIO₄ / tetrahydrofuran; methanol; H₂O / 6 h / 20 °C

5.1: 96 percent / NaBH₄ / methanol / 2 h / 0 °C

6.1: 92 percent / n-Bu₃P / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; tributylphosphine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-00-9051

Reference yield:

: 994-30-9
triethylsilyl chloride

: 325735-55-5
10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 4 steps

1.1: imidazole / dimethylformamide / 2 h / 20 °C

2.1: OsO₄; NMO / tetrahydrofuran; H₂O / 15 h / 20 °C

2.2: NaIO₄ / tetrahydrofuran; methanol; H₂O / 6 h / 20 °C

3.1: 96 percent / NaBH₄ / methanol / 2 h / 0 °C

4.1: 92 percent / n-Bu₃P / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; tributylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-00-9051