(1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide

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Chemical Name:(1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide
CAS No.:422323-02-2
Molecular Formula:C₄₁H₄₈F₂N₂O₆Si
Molecular Weight:730.924
Hs Code.:

(1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide

Synonyms:(1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide

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Chemical Property of (1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide

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Technology Process of (1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide

There total 6 articles about (1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 343566-43-8
(2R)-3-(3',4'-difluorophenyl)-2-hydroxypropionic acid

: (S)-3-[(S)-2-Amino-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-1-(2,4-dimethoxy-benzyl)-pyrrolidin-2-one

: 422323-02-2
(1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; at 23 ℃; for 2.5h;
DOI:10.1021/jm010469k

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 422323-02-2
(1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 23 °C

2: HCl / dioxane / 1.25 h / 23 °C

3: 1.07 g / 4-methylmorpholine; HATU / acetonitrile / 2.5 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 223526-33-8
(1S,3'S)-<2-<1'-(2'',4''-dimethoxybenzyl)-2'-oxo-pyrrolidin-3'-yl>-1-hydroxymethylethyl>-carbamic acid tert-butyl ester

: 422323-02-2
(1S,2'''R,3'S)-N-{2-(tert-butyldiphenylsilanyloxy)-1-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-ylmethyl]ethyl}-3'''-(3'''',4''''-difluorophenyl)-2'''-hydroxypropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 23 °C

2: HCl / dioxane / 1.25 h / 23 °C

3: 1.07 g / 4-methylmorpholine; HATU / acetonitrile / 2.5 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm010469k