tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate

Base Information

Chemical Name:tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate
CAS No.:1365840-92-1
Molecular Formula:C₂₆H₃₄F₃NO₃Si
Molecular Weight:493.642
Hs Code.:

Synonyms:tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate

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Chemical Property of tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate

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Technology Process of tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate

There total 5 articles about tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1365840-91-0
tris(propan-2-yl)silyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}carbamate

: 1365840-92-1
tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate

Guidance literature:: tris(propan-2-yl)silyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}carbamate; With osmium(VIII) oxide; In tetrahydrofuran; water; toluene; for 0.133333h;

With sodium periodate; In tetrahydrofuran; water; toluene; for 1h;
DOI:10.1021/jo3001657

Reference yield:

: 1365840-89-6
tert-butyl N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}-carbamate

: 1365840-92-1
tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h

1.2: 19.5 h

2.1: 2,6-dimethylpyridine / 1,1-dichloroethane / 4 h / 96 °C

3.1: osmium(VIII) oxide / tetrahydrofuran; water; toluene / 0.13 h

3.2: 1 h

With 2,6-dimethylpyridine; osmium(VIII) oxide; sodium hydride; In tetrahydrofuran; 1,1-dichloroethane; water; N,N-dimethyl-formamide; toluene; oil;
DOI:10.1021/jo3001657

Reference yield:

: 771582-26-4
(2-bromo-5-(trifluoromethyl)phenyl)methanamine

: 1365840-92-1
tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 14 h

2.1: palladium diacetate; triphenylphosphine / toluene / 19.08 h / 110 - 120 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h

3.2: 19.5 h

4.1: 2,6-dimethylpyridine / 1,1-dichloroethane / 4 h / 96 °C

5.1: osmium(VIII) oxide / tetrahydrofuran; water; toluene / 0.13 h

5.2: 1 h

With 2,6-dimethylpyridine; osmium(VIII) oxide; palladium diacetate; sodium hydride; triphenylphosphine; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; oil;
DOI:10.1021/jo3001657