α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate

Base Information

Chemical Name:α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate
CAS No.:124153-32-8
Molecular Formula:C₅₂H₇₁F₃N₁₀O₁₆
Molecular Weight:1149.19
Hs Code.:

α-tert-butyl N<sup>10</sup>-(trifluoroacetyl)pteroyltetraglutamate

Synonyms:α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate

Suppliers and Price of α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate

Chemical Property:

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Technology Process of α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate

There total 4 articles about α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 45120-30-7
L-glutamic acid α-tert-butyl ester

: 124153-32-8
α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 10percent Na₂CO₃ / dioxane / 20 h / 24 °C

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

3: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

With piperidine; 4-methyl-morpholine; dmap; KH polyamide resin; sodium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00164a038

Reference yield:

: 84793-07-7
Fmoc-Glu-OtBu

: 124153-32-8
α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

2: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

With piperidine; 4-methyl-morpholine; dmap; KH polyamide resin; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00164a038

Reference yield:

: 37793-53-6
N¹⁰-(trifluoroacetyl)pteroic acid

: 124153-32-8
α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltetraglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylsulfoxide; dimethylformamide / 30 h / 0 °C

2: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

With piperidine; 4-methyl-morpholine; dmap; KH polyamide resin; trifluoroacetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a038