[3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol

Base Information

Chemical Name:[3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol
CAS No.:308805-02-9
Molecular Formula:C₃₁H₃₂O₇
Molecular Weight:516.591
Hs Code.:

Synonyms:[3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol

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Chemical Property of [3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol

Chemical Property:

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Technology Process of [3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol

There total 12 articles about [3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 308805-00-7
Methyl 3-(4-{2-[3,6-dimethoxy-2-(3-methyloxycarbonylphenoxy)phenyl]ethyl}phenoxy)-4-methoxybenzoate

: 308805-02-9
[3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;
DOI:10.1055/s-2000-7106

Reference yield:

: 393-85-1
methyl 5-fluoro-2-nitrobenzoate

: 308805-02-9
[3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / K₂CO₃ / dimethylformamide / 24 h / 90 °C

2.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate / 2 h / 20 °C / 2250.18 - 3750.3 Torr

3.1: aq. NaNO₂; HCl; HOAc / 0.33 h / 0 °C

3.2: 70 percent / aq. H₃PO₂ / 12 h / 0 °C

4.1: 86 percent / LiAlH₄ / tetrahydrofuran / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; potassium carbonate; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 1.1: Etherification / 2.1: Reduction / 3.1: Diazotization / 3.2: Substitution / 4.1: Reduction;
DOI:10.1055/s-2000-7106

Reference yield:

: 64466-51-9
3,6-Dimethoxy-2-hydroxybenzaldehyde

: 308805-02-9
[3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 60 percent / K₂CO₃ / methanol / Heating

2.1: 76 percent / K₂CO₃; 18-crown-6 / toluene / 24 h / Heating

3.1: 84 percent / H₂ / 5 percent Pd/C / ethyl acetate / 24 h / 20 °C / 2250.18 - 3750.3 Torr

4.1: 99 percent / K₂CO₃ / dimethylformamide / 24 h / 90 °C

5.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate / 2 h / 20 °C / 2250.18 - 3750.3 Torr

6.1: aq. NaNO₂; HCl; HOAc / 0.33 h / 0 °C

6.2: 70 percent / aq. H₃PO₂ / 12 h / 0 °C

7.1: 86 percent / LiAlH₄ / tetrahydrofuran / Heating

With hydrogenchloride; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; potassium carbonate; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Etherification / 2.1: Condensation / 3.1: Hydrogenation / 4.1: Etherification / 5.1: Reduction / 6.1: Diazotization / 6.2: Substitution / 7.1: Reduction;
DOI:10.1055/s-2000-7106