2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene

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Chemical Name:2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene
CAS No.:308805-03-0
Molecular Formula:C₃₁H₃₀Cl₂O₅
Molecular Weight:553.482
Hs Code.:

Synonyms:2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene

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Chemical Property of 2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene

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Technology Process of 2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene

There total 13 articles about 2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 308805-02-9
[3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol

: 308805-03-0
2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene

Guidance literature:: With thionyl chloride; In diethyl ether; for 2h; Heating;
DOI:10.1055/s-2000-7106

Reference yield:

: 393-85-1
methyl 5-fluoro-2-nitrobenzoate

: 308805-03-0
2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / K₂CO₃ / dimethylformamide / 24 h / 90 °C

2.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate / 2 h / 20 °C / 2250.18 - 3750.3 Torr

3.1: aq. NaNO₂; HCl; HOAc / 0.33 h / 0 °C

3.2: 70 percent / aq. H₃PO₂ / 12 h / 0 °C

4.1: 86 percent / LiAlH₄ / tetrahydrofuran / Heating

5.1: 82 percent / SOCl₂ / diethyl ether / 2 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; 1.1: Etherification / 2.1: Reduction / 3.1: Diazotization / 3.2: Substitution / 4.1: Reduction / 5.1: Substitution;
DOI:10.1055/s-2000-7106

Reference yield:

: 64466-51-9
3,6-Dimethoxy-2-hydroxybenzaldehyde

: 308805-03-0
2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 60 percent / K₂CO₃ / methanol / Heating

2.1: 76 percent / K₂CO₃; 18-crown-6 / toluene / 24 h / Heating

3.1: 84 percent / H₂ / 5 percent Pd/C / ethyl acetate / 24 h / 20 °C / 2250.18 - 3750.3 Torr

4.1: 99 percent / K₂CO₃ / dimethylformamide / 24 h / 90 °C

5.1: 100 percent / H₂ / 5 percent Pd/C / ethyl acetate / 2 h / 20 °C / 2250.18 - 3750.3 Torr

6.1: aq. NaNO₂; HCl; HOAc / 0.33 h / 0 °C

6.2: 70 percent / aq. H₃PO₂ / 12 h / 0 °C

7.1: 86 percent / LiAlH₄ / tetrahydrofuran / Heating

8.1: 82 percent / SOCl₂ / diethyl ether / 2 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; hydrogen; potassium carbonate; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Etherification / 2.1: Condensation / 3.1: Hydrogenation / 4.1: Etherification / 5.1: Reduction / 6.1: Diazotization / 6.2: Substitution / 7.1: Reduction / 8.1: Substitution;
DOI:10.1055/s-2000-7106