(Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)acetic acid O-(tert-butyldimethylsilyl)hydroxyamide

Base Information

• Chemical Name: (Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)acetic acid O-(tert-butyldimethylsilyl)hydroxyamide
• CAS No.: 1257346-71-6
• Molecular Formula: C₂₆H₃₂FNO₂SSi
• Molecular Weight: 469.695
• Mol file: 1257346-71-6.mol

Synonyms:(Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)acetic acid O-(tert-butyldimethylsilyl)hydroxyamide

Chemical Property of (Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)acetic acid O-(tert-butyldimethylsilyl)hydroxyamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)acetic acid O-(tert-butyldimethylsilyl)hydroxyamide

There total 1 articles about (Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)acetic acid O-(tert-butyldimethylsilyl)hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

O-(tert-butyldimethylsilanyl)hydroxylamine (41879-39-4) + sulindac sulfide (49627-27-2) → (Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)acetic acid O-(tert-butyldimethylsilyl)hydroxyamide (1257346-71-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 25 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.08.019

Reference yield: 70.0%

(Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)acetic acid O-(tert-butyldimethylsilyl)hydroxyamide (1257346-71-6) → (Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)-N-hydroxyacetamide (1257346-68-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.08.019

upstream raw materials:

O-(tert-butyldimethylsilanyl)hydroxylamine

sulindac sulfide

Downstream raw materials:

(Z)-2-(6-fluoro-2-methyl-3-(4-(methylthio)benzylidene)-3H-inden-1-yl)-N-hydroxyacetamide