3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea

Base Information

Chemical Name:3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea
CAS No.:1417446-52-6
Molecular Formula:C₂₅H₂₇FN₂O₂
Molecular Weight:406.5
Hs Code.:

Synonyms:3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea

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Chemical Property of 3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea

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Technology Process of 3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea

There total 4 articles about 3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1417446-18-4
C₁₈H₁₉FN₂O

: 14774-77-7
p-methoxyphenyllithium

: 1417446-52-6
3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea

Guidance literature:: p-methoxyphenyllithium; With (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

C₁₈H₁₉FN₂O; In tetrahydrofuran; at -78 ℃; for 1.5h; Further stages; Inert atmosphere;
DOI:10.1021/ol3029324

Reference yield:

: 6907-71-7
N-(1-phenylethylidene)methanamine

: 1417446-52-6
3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

3.1: (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 °C / Inert atmosphere

With sodium hydride; (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine; In tetrahydrofuran;
DOI:10.1021/ol3029324

Reference yield:

: 98-86-2
acetophenone

: 1417446-52-6
3-ethyl-1-(1-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-phenylethyl)-1-methylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 48 h / 20 °C / Molecular sieve; Inert atmosphere

2.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

4.1: (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

4.2: 1.5 h / -78 °C / Inert atmosphere

With sodium hydride; (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine; In tetrahydrofuran; ethanol;
DOI:10.1021/ol3029324