2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione
CAS No.:956234-81-4
Molecular Formula:C₂₅H₃₀Cl₂N₂O₃
Molecular Weight:477.431
Hs Code.:

Synonyms:2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione

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Chemical Property of 2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Chemical Property:

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Technology Process of 2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione

There total 6 articles about 2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 956234-79-0
3-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}propyl methanesulfonate

: 15205-19-3
1-(2,6-dichlorophenyl)-N-methylmethanamine

: 956234-81-4
2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 45 ℃; for 18h;

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 956234-81-4
2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / tetrabutylammomium bromide / water / 20 h / 20 °C

2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 20 - 75 °C

3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / 20 °C / 1965.2 Torr

4: triethylamine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / 18 h / 45 °C

With sodium hydroxide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 956234-76-7
({3-[(6-bromohexyl)oxy]propoxy}methyl)benzene

: 956234-81-4
2-(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 20 - 75 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / 20 °C / 1965.2 Torr

3: triethylamine / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / 18 h / 45 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; cetyltributylphosphonium bromide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;