1-(Phenoxyacetyl)piperidine

Base Information

• Chemical Name: 1-(Phenoxyacetyl)piperidine
• CAS No.: 36405-75-1
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• DSSTox Substance ID: DTXSID80877252
• Nikkaji Number: J1.584.640B
• Wikidata: Q82859006
• Mol file: 36405-75-1.mol

Synonyms:1-(phenoxyacetyl)piperidine;36405-75-1;2-phenoxy-1-(piperidin-1-yl)ethanone;2-phenoxy-1-piperidin-1-ylethanone;CBMicro_016676;Cambridge id 5314405;N-PHENOXYACETYLPIPERIDINE;SCHEMBL10064244;DTXSID80877252;CCG-5902;STL355841;AKOS002263941;2-phenoxy-1-(piperidin-1-yl)ethan-1-one;BIM-0016913.P001;AB00080272-01;SR-01000204189;SR-01000204189-1

Chemical Property of 1-(Phenoxyacetyl)piperidine

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 219.125928785
• Heavy Atom Count: 16
• Complexity: 218

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)COC2=CC=CC=C2

Technology Process of 1-(Phenoxyacetyl)piperidine

There total 4 articles about 1-(Phenoxyacetyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + phenoxyacetic acid ethyl ester (2555-49-9) → 2-phenoxy-1-(piperidin-1-yl)ethanone (36405-75-1)

Guidance literature:

With iron(III) chloride; In neat (no solvent); at 80 ℃; Sealed tube;

DOI:10.3390/molecules25051040

Reference yield:

piperidine (110-89-4) + Phenoxyacetyl chloride (701-99-5) → 2-phenoxy-1-(piperidin-1-yl)ethanone (36405-75-1)

Guidance literature:

With morpholinomethyl polystyrene HL; In dichloromethane; at 20 ℃;

DOI:10.1081/SCC-100103528

Reference yield:

2-phenoxyacetic acid (122-59-8) → 2-phenoxy-1-(piperidin-1-yl)ethanone (36405-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: PS-Ph₃P resin; trichloroacetonitrile / CH₂Cl₂ / 20 °C

2: morpholinomethyl polystyrene HL / CH₂Cl₂ / 20 °C

With morpholinomethyl polystyrene HL; PS-Ph₃P resin; trichloroacetonitrile; In dichloromethane;

DOI:10.1081/SCC-100103528

upstream raw materials:

piperidine

Phenoxyacetyl chloride

2-phenoxyacetic acid

phenoxyacetic acid ethyl ester

Downstream raw materials:

phenoxythioacetopiperidide

4-oxo-4-[4-(2-oxo-2-piperidin-1-yl-ethoxy)phenyl]butyric acid

3-methyl-4-oxo-4-[4-(2-oxo-2-piperidin-1-yl-ethoxy)phenyl]-butyric-acid

N-Formylpiperidine