N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester

Base Information

• Chemical Name: N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester
• CAS No.: 176755-93-4
• Molecular Formula: C₂₄H₂₀N₂O₆
• Molecular Weight: 432.433
• Mol file: 176755-93-4.mol

Synonyms:N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester

Chemical Property of N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester

There total 2 articles about N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + N-Fmoc-β-alanine (35737-10-1) → N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester (176755-93-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane; at 20 ℃; for 24h;

Reference yield:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester (176755-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Et₃N / H₂O / 0.5 h

2: 95 percent / dicyclohexylcarbodiimide / dioxane / 24 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; water;

DOI:10.1080/07328319608002138

Reference yield: 63.0%

2-amino-1-O-(4,4'-dimethoxytrityl)propane-1,3-diol (154928-41-3) + N-(9-fluorenylmethoxycarbonyl)-β-alanine p-nitrophenyl ester (176755-93-4) → 3-dimethoxytrityloxy-2-<amino>propanol (176755-94-5)

Guidance literature:

With 1H-imidazole; In 1,4-dioxane; at 20 ℃; for 24h;

upstream raw materials:

4-nitro-phenol

N-Fmoc-β-alanine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

3-dimethoxytrityloxy-2-<amino>propanol