C₁₈H₁₁FN₂O₂

Base Information

• Chemical Name: C₁₈H₁₁FN₂O₂
• CAS No.: 1266161-22-1
• Molecular Formula: C₁₈H₁₁FN₂O₂
• Molecular Weight: 306.296
• Mol file: 1266161-22-1.mol

Synonyms:C₁₈H₁₁FN₂O₂

Chemical Property of C₁₈H₁₁FN₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₁FN₂O₂

There total 4 articles about C₁₈H₁₁FN₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-5-(4-phenoxyphenyl)isonicotinonitrile (1266161-20-9) → C18H11FN2O2 (1266161-22-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

3,5-dichloropyridine-4-carbonitrile (153463-65-1) → C18H11FN2O2 (1266161-22-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 20 h / Inert atmosphere; Sealed tube; Reflux

2: potassium fluoride / dimethyl sulfoxide / 240 h / 120 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

With potassium fluoride; potassium phosphate; 3-chloro-benzenecarboperoxoic acid; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

4-phenoxyphenylboronic acid (51067-38-0) → C18H11FN2O2 (1266161-22-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 20 h / Inert atmosphere; Sealed tube; Reflux

2: potassium fluoride / dimethyl sulfoxide / 240 h / 120 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

With potassium fluoride; potassium phosphate; 3-chloro-benzenecarboperoxoic acid; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

3,5-dichloropyridine-4-carbonitrile

4-phenoxyphenylboronic acid

3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile

3-fluoro-5-(4-phenoxyphenyl)isonicotinonitrile

Downstream raw materials:

2-chloro-5-fluoro-3-(4-phenoxyphenyl)isonicotinonitrile

2-chloro-3-fluoro-5-(4-phenoxyphenyl)isonicotnonitrile

tert-butyl 3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzycarbamate

N-(3-(4-cyano-3-fluoro-5-(4-phenoxyphenyl)pyridin-2-yl)benzyl)acetamide