1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

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Chemical Name:1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea
CAS No.:1401344-84-0
Molecular Formula:C₃₆H₃₇N₇O₆
Molecular Weight:663.733
Hs Code.:

1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

Synonyms:1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

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Chemical Property of 1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

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Technology Process of 1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

There total 12 articles about 1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1401344-83-9
1-((S)-1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

: 1401344-84-0
1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/c2cc34791a

Reference yield:

: 1401344-71-5
N-(1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-3-nitroaniline

: 1401344-84-0
1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

Guidance literature:: Multi-step reaction with 12 steps

1: dmap / dichloromethane / 48 h / 20 °C

2: tetrabutyl ammonium fluoride; acetic acid / 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C

4: 5% Pd/C / ethanol / Inert atmosphere

5: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

6: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

7: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

8: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

9: acetic acid; 5% Pd/C / ethanol; toluene / 3 h / Inert atmosphere

10: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

11: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

12: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

With dmap; di-isopropyl azodicarboxylate; 5% Pd/C; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; triphenylphosphine; urea; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1039/c2cc34791a

Reference yield:

: 1401344-70-4
(S)-2-((3-nitrophenyl)amino)propan-1-ol

: 1401344-84-0
1-((S)-1-hydroxypropan-2-yl)-3-(3-((S)-5-methyl-3-(3-((S)-5-methyl-2-oxo-3-phenylimidazolidin-1-yl)phenyl)-2-oxoimidazolidin-1-yl)phenyl)-1-(3-nitrophenyl)urea

Guidance literature:: Multi-step reaction with 13 steps

1: dmap; 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: dmap / dichloromethane / 48 h / 20 °C

3: tetrabutyl ammonium fluoride; acetic acid / 20 °C / Inert atmosphere

4: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C

5: 5% Pd/C / ethanol / Inert atmosphere

6: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

7: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

8: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

9: di-isopropyl azodicarboxylate; triphenylphosphine; urea / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

10: acetic acid; 5% Pd/C / ethanol; toluene / 3 h / Inert atmosphere

11: sodium hydrogencarbonate / dichloromethane; water / Inert atmosphere

12: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

13: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C

With 1H-imidazole; dmap; di-isopropyl azodicarboxylate; 5% Pd/C; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; triphenylphosphine; urea; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c2cc34791a