5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

Base Information

Chemical Name:5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine
CAS No.:917364-07-9
Molecular Formula:C₂₈H₂₅ClN₆
Molecular Weight:481
Hs Code.:

Synonyms:5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

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Chemical Property of 5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

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Technology Process of 5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

There total 9 articles about 5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 893424-25-4
4-(1H-1,2,4-triazol-3-yl)piperidine

: 917363-90-7
4-(5-chloro-3-phenyl-[1,6]naphthyridin-2-yl)-benzaldehyde

: 917364-07-9
5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield:

: 161609-84-3
4-cyanopiperidine-1-carboxylic acid benzyl ester

: 917364-07-9
5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 0.5 h / 20 °C

1.2: 96 h / Heating / reflux

1.3: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h

3.1: sodium tris(acetoxy)borohydride; acetic acid; triethylamine / 1-methyl-pyrrolidin-2-one / 20 °C

With hydrogen; sodium methylate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; ethanol;

Reference yield:

: 893424-27-6
benzyl 4-(1H-1,2,4-triazol-3-yl)piperidine-1-carboxylate

: 917364-07-9
5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h

2: sodium tris(acetoxy)borohydride; acetic acid; triethylamine / 1-methyl-pyrrolidin-2-one / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol;