Technology Process of 1-Piperidinecarboxylic acid, 4-(1H-1,2,4-triazol-3-yl)-, phenylmethyl
ester
There total 1 articles about 1-Piperidinecarboxylic acid, 4-(1H-1,2,4-triazol-3-yl)-, phenylmethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-cyanopiperidine-1-carboxylic acid benzyl ester;
With
sodium methylate;
In
methanol;
at 20 ℃;
for 0.5h;
formic acid hydrazide;
In
methanol;
for 96h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h
2.1: sodium tris(acetoxy)borohydride; acetic acid; triethylamine / 1-methyl-pyrrolidin-2-one / 20 °C
3.1: hydrazine / 1,4-dioxane / 0.08 h / 100 °C / Microwave reactor
4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.2 h / 80 °C / Microwave reactor
4.2: 0.17 h / 80 °C / Microwave reactor
With
hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine;
palladium 10% on activated carbon;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h
2: sodium tris(acetoxy)borohydride; acetic acid; triethylamine / 1-methyl-pyrrolidin-2-one / 20 °C
With
hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine;
palladium 10% on activated carbon;
In
1-methyl-pyrrolidin-2-one; ethanol;
