161609-84-3

Usage

Uses

Used in Pharmaceutical Synthesis:
1-N-Cbz-4-cyanopiperidine is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to protect the nitrogen atom and provide a reactive site for further chemical modifications. This dual functionality makes it a valuable component in the creation of new drug molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the realm of organic synthesis, 1-N-Cbz-4-cyanopiperidine serves as a crucial building block. It is used as a starting material for the production of various organic molecules with a range of biological activities. 1-N-Cbz-4-cyanopiperidine's structural features facilitate the synthesis of complex organic molecules, contributing to the development of novel chemical entities with potential applications in various industries.
Used in Drug Development:
1-N-Cbz-4-cyanopiperidine is employed as a component in drug development processes. Its protective and reactive properties allow for the exploration of new chemical pathways and the synthesis of innovative drug candidates. 1-N-Cbz-4-cyanopiperidine plays a significant role in advancing the discovery and design of pharmaceuticals with improved efficacy and selectivity.
Used in Chemical Research:
In the field of chemical research, 1-N-Cbz-4-cyanopiperidine is used as a model compound to study various reaction mechanisms and to develop new synthetic methodologies. Its unique structure provides researchers with opportunities to explore novel chemical transformations and to gain insights into the reactivity of nitrogen-containing compounds.
Overall, 1-N-Cbz-4-cyanopiperidine is a multifaceted chemical entity with applications spanning across pharmaceuticals, organic synthesis, drug development, and chemical research. Its protective and reactive features make it an indispensable tool in the advancement of chemical science and the creation of new molecules with therapeutic potential.

InChI:InChI=1/C14H16N2O2/c15-10-12-6-8-16(9-7-12)14(17)18-11-13-4-2-1-3-5-13/h1-5,12H,6-9,11H2

Upstream product

• 288-32-4 1H-imidazole 
• 144-55-8 sodium hydrogencarbonate 
• 167757-45-1 4-Carbamoylpiperidine-1-carboxylic acid benzyl ester 
• 138163-08-3 N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde 
• 138163-07-2 piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-methyl ester 
• 199103-19-0 benzyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate 

Downstream Products

• 476492-92-9 3-(1-benzyloxycarbonylpiperidin-4-yl)-2H-isoquinolin-1-one 
• 476492-94-1 3-(1-benzyloxycarbonylpiperidin-4-yl)-4-phenyl-2H-isoquinolin-1-one 
• 161609-85-4 1-Benzyloxycarbonyl-4-piperidinecarboxamideoxime 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 917364-08-0 5-hydrazino-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine 
• 917364-07-9 5-chloro-3-phenyl-2-(4-{[4-(4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine 
• 1609735-05-8 benzyl 4-cyano-4-(quinazolin-4-yl)piperidine-1-carboxylate 
• 1372532-58-5 benzyl 4-(aminomethyl)-4-cyanopiperidine-1-carboxylate 
• 1372534-37-6 benzyl 4-cyano-4-methylpiperidine-1-carboxylate 
• 893424-27-6 benzyl 4-(1H-1,2,4-triazol-3-yl)piperidine-1-carboxylate 
• 959689-78-2 Benzyl 4-((2-chloroethoxy)methyl)-4-cyanopiperidine-1-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Synthesis of Nitriles from Aldoximes and Primary Amides Using XtalFluor-E

The dehydration reaction of aldoximes and amides for the synthesis of nitriles using [Et2NSF2]BF4 (XtalFluor-E) is described. Overall, the reaction proceeds rapidly (normally 1 h) at room temperature in an environmentally benign solvent (EtOAc) with only a slight excess of the dehydrating agent (1.1 equiv). A broad scope of nitriles can be prepared, including chiral nonracemic ones. In addition, in a number of cases, further purification of the nitrile after the workup was not required.

Nitrilase-catalyzed enantioselective synthesis of pyrrolidine- And piperidinecarboxylic acids

The enantioselective synthesis of the nonproteinogenic amino acids β-proline and nipecotic acids from their readily available nitriles is achieved in high enantiomeric excess by commercially available nitrilases. The presented procedure comprises not more than 4 steps, thus considerably reducing the multiple steps generally required. Amide formation is also observed for specific heterocyclic nitriles.

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.