(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate

Base Information

Chemical Name:(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate
CAS No.:921202-55-3
Molecular Formula:C₂₅H₂₈F₂O₆S
Molecular Weight:494.557
Hs Code.:

Synonyms:(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate

Suppliers and Price of (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate

There total 2 articles about (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: Benzoic acid (2R,4R)-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-2-trifluoromethanesulfonyloxy-butyl ester

: 507-09-5
tiolacetic acid

: 921202-55-3
(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate

Guidance literature:: With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 13h;
DOI:10.1021/ol062576k

Reference yield:

: 634181-81-0
(2R,4R)-4-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluoro-2-hydroxybutyl benzoate

: 921202-55-3
(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / -40 - -20 °C

2: 86 percent / CsF / dimethylformamide / 13 h / 20 °C

With pyridine; cesium fluoride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol062576k

Reference yield: 64.0%

: 921202-55-3
(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate

: 2-O-benzyl-5-O-benzoyl-3-deoxy-3,3-difluoro-4-thio-L-xylofuranose

Guidance literature:: (2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O,O-isopropylidenehex-2-yl ethanethioate; With trifluoroacetic acid; In tetrahydrofuran; water; for 1h;

With sodium periodate; In methanol; water; for 1.5h;

With hydrogenchloride; In methanol;
DOI:10.1021/ol062576k