7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

Base Information

Chemical Name:7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline
CAS No.:1300031-50-8
Molecular Formula:C₂₉H₃₀N₄O₃
Molecular Weight:482.582
Hs Code.:

Synonyms:7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

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Chemical Property of 7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

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Technology Process of 7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

There total 10 articles about 7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 40191-32-0
tetrahydro-2H-pyran-4-carbonylchloride

: 1300031-63-3
7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N⁴-((R)-1-phenylethyl)quinoline-3,4-diamine

: 1300031-50-8
7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

Guidance literature:: tetrahydro-2H-pyran-4-carbonylchloride; 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N⁴-((R)-1-phenylethyl)quinoline-3,4-diamine; In dichloromethane; at 0 ℃; for 0.25h;

With sodium hydrogencarbonate; In dichloromethane; water;

With acetic acid; at 100 ℃;

Reference yield:

: 40191-32-0
tetrahydro-2H-pyran-4-carbonylchloride

: 1300031-50-8
7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

Guidance literature:: With sodium hydrogencarbonate; acetic acid; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

: 74587-12-5
3-iodo-4-methoxyaniline

: 1300031-50-8
7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1 h / Reflux

1.2: 1 h / Reflux

2.1: diphenylether / 0.17 h / 260 °C

3.1: barium hydroxide octahydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 105 °C / Inert atmosphere

4.1: nitric acid; propionic acid / 1 h / 100 °C

5.1: trichlorophosphate / Reflux

6.1: acetonitrile / 2 h / 60 °C

7.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 1 h / 40 °C

8.1: dichloromethane / 0.25 h / 0 °C

8.2: 100 °C

With hydrogenchloride; tin(II) chloride dihdyrate; barium hydroxide octahydrate; nitric acid; propionic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; diphenylether; ethanol; dichloromethane; water; acetonitrile; 3.1: Suzuki Coupling;