1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Base Information

Chemical Name:1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile
CAS No.:1416324-16-7
Molecular Formula:C₂₆H₂₈N₄O₄
Molecular Weight:460.533
Hs Code.:

Synonyms:1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

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Chemical Property of 1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

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Technology Process of 1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

There total 9 articles about 1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1416324-15-6
1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

: 1416324-16-7
1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Guidance literature:: 1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile; With hydrogen bromide; In 1,4-dioxane; water; at 80 ℃; for 32h;

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; pH=11;

Reference yield:

: 1416324-51-0
methyl 3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-16-7
1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4.1: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

5.1: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

6.1: potassium carbonate / acetonitrile / 15 h / 20 °C

7.1: formic acid; iron / methanol / 19 h / 65 °C

8.1: hydrogen bromide / 1,4-dioxane; water / 32 h / 80 °C

8.2: 20 °C / pH 11

With sodium tetrahydroborate; lithium aluminium tetrahydride; formic acid; sodium azide; nickel (II) chloride hexahydrate; hydrogen bromide; sodium hexamethyldisilazane; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1416324-52-1
methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-16-7
1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3.1: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

4.1: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

5.1: potassium carbonate / acetonitrile / 15 h / 20 °C

6.1: formic acid; iron / methanol / 19 h / 65 °C

7.1: hydrogen bromide / 1,4-dioxane; water / 32 h / 80 °C

7.2: 20 °C / pH 11

With sodium tetrahydroborate; lithium aluminium tetrahydride; formic acid; sodium azide; nickel (II) chloride hexahydrate; hydrogen bromide; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;