1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Base Information

Chemical Name:1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile
CAS No.:1416324-15-6
Molecular Formula:C₃₃H₃₄N₄O₄
Molecular Weight:550.657
Hs Code.:

Synonyms:1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

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Chemical Property of 1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

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Technology Process of 1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

There total 8 articles about 1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.3%

: 1416324-57-6
3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

: 149-73-5
trimethyl orthoformate

: 1416324-15-6
1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Guidance literature:: 3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile; trimethyl orthoformate; With formic acid; iron; In methanol; at 65 ℃; for 19h;

With sodium hydroxide;

Reference yield:

: 1416324-51-0
methyl 3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-15-6
1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4.1: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

5.1: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

6.1: potassium carbonate / acetonitrile / 15 h / 20 °C

7.1: formic acid; iron / methanol / 19 h / 65 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; formic acid; sodium azide; nickel (II) chloride hexahydrate; sodium hexamethyldisilazane; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1416324-52-1
methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-15-6
1-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

4: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

5: potassium carbonate / acetonitrile / 15 h / 20 °C

6: formic acid; iron / methanol / 19 h / 65 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; formic acid; sodium azide; nickel (II) chloride hexahydrate; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;