1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate

Base Information

Chemical Name:1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate
CAS No.:1416324-58-7
Molecular Formula:C₂₇H₃₀N₄O₆S
Molecular Weight:538.624
Hs Code.:

Synonyms:1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate

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Chemical Property of 1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate

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Technology Process of 1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate

There total 10 articles about 1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.2%

: 1416324-16-7
1-((-7-(hydroxymethyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

: 124-63-0
methanesulfonyl chloride

: 1416324-58-7
1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1416324-51-0
methyl 3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-58-7
1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

3.1: lithium borohydride / tetrahydrofuran / 72.5 h / 20 - 50 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

5.1: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

6.1: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

7.1: potassium carbonate / acetonitrile / 15 h / 20 °C

8.1: formic acid; iron / methanol / 19 h / 65 °C

9.1: hydrogen bromide / 1,4-dioxane; water / 32 h / 80 °C

9.2: 20 °C / pH 11

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; lithium borohydride; formic acid; sodium azide; nickel (II) chloride hexahydrate; hydrogen bromide; sodium hexamethyldisilazane; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1416324-52-1
methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-58-7
1-(7-((6-cyano-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3.1: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

4.1: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

5.1: potassium carbonate / acetonitrile / 15 h / 20 °C

6.1: formic acid; iron / methanol / 19 h / 65 °C

7.1: hydrogen bromide / 1,4-dioxane; water / 32 h / 80 °C

7.2: 20 °C / pH 11

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; formic acid; sodium azide; nickel (II) chloride hexahydrate; hydrogen bromide; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;