(2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt

Base Information

Chemical Name:(2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt
CAS No.:1189569-43-4
Molecular Formula:C₂HF₃O₂*C₃₄H₃₄F₂N₄O₂
Molecular Weight:682.69
Hs Code.:

(2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt

Synonyms:(2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt

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Chemical Property of (2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt

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Technology Process of (2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt

There total 12 articles about (2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₄₈F₂N₄O₃Si

: 76-05-1
trifluoroacetic acid

: 1189569-43-4
(2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt

Guidance literature:: C₄₀H₄₈F₂N₄O₃Si; With ethylenediamine; sodium hydroxide; In methanol; water; for 0.5h; pH=10;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 879132-46-4
1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 1189569-43-4
(2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

2.1: water

3.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

4.1: caesium carbonate / methanol / 18 h

5.1: sodium acetate / tris(o-methoxyphenyl)phosphine; palladium diacetate / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation

6.1: potassium hydroxide / diethyl ether; water / 0.25 h / -78 °C

6.2: 18 h / 20 °C

7.1: trifluoroacetic acid / 0.5 h / 20 °C

8.1: ethylenediamine; sodium hydroxide / methanol; water / 0.5 h / pH 10

With water; sodium acetate; pyridinium hydrobromide perbromide; ammonium chloride; caesium carbonate; ethylenediamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; zinc; tris(o-methoxyphenyl)phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 271-63-6
7-Azaindole

: 1189569-43-4
(2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.42 h / 0 °C

1.2: 1.25 h / 10 °C

2.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

3.1: water

4.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

5.1: caesium carbonate / methanol / 18 h

6.1: sodium acetate / tris(o-methoxyphenyl)phosphine; palladium diacetate / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation

7.1: potassium hydroxide / diethyl ether; water / 0.25 h / -78 °C

7.2: 18 h / 20 °C

8.1: trifluoroacetic acid / 0.5 h / 20 °C

9.1: ethylenediamine; sodium hydroxide / methanol; water / 0.5 h / pH 10

With water; sodium acetate; pyridinium hydrobromide perbromide; sodium hydride; ammonium chloride; caesium carbonate; ethylenediamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; zinc; tris(o-methoxyphenyl)phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; N,N-dimethyl-formamide; mineral oil;