1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Base Information

• Chemical Name: 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
• CAS No.: 879132-48-6
• Molecular Formula: C13H20N2O2Si
• Molecular Weight: 264.4
• Hs Code.: 2933990090
• Mol file: 879132-48-6.mol

Synonyms:1-(2-trimethylsilylethoxymethyl)-3H-pyrrolo[2,3-b]pyridin-2-one;

Chemical Property of 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Chemical Property:

• PSA: 42.43000
• LogP: 2.34800
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

There total 6 articles about 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3,3-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydro-2H-pyrrolo[2.3-b]pyridin-2-one (879132-47-5) → 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (879132-48-6)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; at 23 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm4013906

Reference yield:

7-azaoxindole (5654-97-7) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (879132-48-6)

Guidance literature:

7-azaoxindole; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 21h; Inert atmosphere;

Reference yield:

1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (879132-46-4) → 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (879132-48-6)

Guidance literature:

1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine; With pyridinium perbromide hydrobromide; In 1,4-dioxane;

With water; ammonium chloride; zinc; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2008.10.106

upstream raw materials:

3,3-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydro-2H-pyrrolo[2.3-b]pyridin-2-one

1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

(2-trimethylethylsilylethoxy)methyl chloride

7-Azaindole

Downstream raw materials:

spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

5-bromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

spiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

5-amino-1‘-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one

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