methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt

Base Information

Chemical Name:methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt
CAS No.:1018987-51-3
Molecular Formula:C₂H₂O₄*C₂₁H₂₁NO₃S
Molecular Weight:457.504
Hs Code.:

Synonyms:methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt

Suppliers and Price of methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt

There total 8 articles about methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: (Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-ol

: 13515-93-0
N-methylglycine methyl ester hydrochloride

: 144-62-7,97993-78-7
oxalic acid

: 1018987-51-3
methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt

Guidance literature:: (Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-ol; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

N-methylglycine methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 4 ℃;

oxalic acid; In ethanol; at 60 ℃;
DOI:10.1021/op900015g

Reference yield: 32.0%

: 1018987-50-2
methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate

: 144-62-7,97993-78-7
oxalic acid

: 1018987-51-3
methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt

Guidance literature:: In ethanol; at 60 ℃;

Reference yield:

: 1018987-52-4
3-[4-(2-furyl)phenyl]-2-propyn-1-ol

: 1018987-51-3
methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 0.5 h / -20 - 0 °C

1.2: 0.5 h / -20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 60 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 °C

5.1: ethanol / 60 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water;