2-Pyridinecarboxylicacid,4-(hydroxymethyl)-,methylester(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxylicacid,4-(hydroxymethyl)-,methylester(9CI)
• CAS No.: 317335-15-2
• Molecular Formula: C8H9 N O3
• Molecular Weight: 167.164
• Hs Code.: 2933399090
• Mol file: 317335-15-2.mol

Synonyms:2-Methoxycarbonylpyridine-4-methanol;4-Hydroxymethylpicolinic acid methyl ester

Chemical Property of 2-Pyridinecarboxylicacid,4-(hydroxymethyl)-,methylester(9CI)

Chemical Property:

• Vapor Pressure: 4.61E-05mmHg at 25°C
• Melting Point: 74-76℃
• Refractive Index: 1.546
• Boiling Point: 335.8°C at 760 mmHg
• PKA: 13.17±0.10(Predicted)
• Flash Point: 156.9°C
• PSA: 59.42000
• Density: 1.244g/cm³
• LogP: 0.36050
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-(hydroxymethyl)picolinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-(hydroxymethyl)pyridine-2 is used as an intermediate in pharmaceuticals and also finds use in chemical research.

Technology Process of 2-Pyridinecarboxylicacid,4-(hydroxymethyl)-,methylester(9CI)

There total 6 articles about 2-Pyridinecarboxylicacid,4-(hydroxymethyl)-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methanol (67-56-1) + 4-(hydroxymethyl)pyridine-2-carboxylic acid (923169-37-3) → methyl 4-(hydroxymethyl)pyridine-2-carboxylate (317335-15-2)

Guidance literature:

With thionyl chloride; for 48h; Reflux;

DOI:10.1016/j.ejmech.2018.12.063

Reference yield:

methanol (67-56-1) + 2-cyano-4-[{(tert-butyldimethylsilyl)oxy}methyl]pyridine (117423-43-5) → methyl 4-(hydroxymethyl)pyridine-2-carboxylate (317335-15-2)

Guidance literature:

With hydrogenchloride; water; for 5h; Heating / reflux;

Reference yield:

pyridine-4-methanol (586-95-8) → methyl 4-(hydroxymethyl)pyridine-2-carboxylate (317335-15-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3.1: N,N-Dimethylcarbamoyl chloride / dichloromethane / 0 - 20 °C

3.2: 0.5 h

4.1: hydrogenchloride; water / 5 h / Heating / reflux

With 1H-imidazole; hydrogenchloride; water; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In DMF (N,N-dimethyl-formamide); dichloromethane;

upstream raw materials:

methanol

2-cyano-4-[{(tert-butyldimethylsilyl)oxy}methyl]pyridine

4-(hydroxymethyl)pyridine-2-carboxylic acid

pyridine-4-methanol

Downstream raw materials:

methyl 4-(methylsulfonyloxymethyl)-2-pyridinecarboxylate

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