(±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane

Base Information

• Chemical Name: (±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane
• CAS No.: 1008108-65-3
• Molecular Formula: C₁₂H₁₆BrF₃OSi
• Molecular Weight: 341.243
• Mol file: 1008108-65-3.mol

Synonyms:(±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane

Chemical Property of (±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane

There total 1 articles about (±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

para-bromoacetophenone (99-90-1) + (trifluoromethyl)trimethylsilane (81290-20-2) → (±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane (1008108-65-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

DOI:10.1021/jacs.8b06777

Reference yield:

(±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane (1008108-65-3) + aniline (62-53-3) → C18H22F3NOSi (1057090-22-8)

Guidance literature:

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 20h;

Reference yield:

(±)-trimethyl({[1,1,1-trifluoro-2-(4-bromophenyl)propan-2-yl]oxy})silane (1008108-65-3) + Cyclopropylamine (765-30-0) → C15H22F3NOSi (920974-14-7)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 80 ℃; for 16h;

upstream raw materials:

para-bromoacetophenone

(trifluoromethyl)trimethylsilane

Downstream raw materials:

C₁₈H₂₂F₃NOSi

C₁₅H₂₂F₃NOSi

C₁₂H₁₄F₃NO

C₁₃H₁₆F₃NO