2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole

Base Information

Chemical Name:2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole
CAS No.:1196103-48-6
Molecular Formula:C₁₈H₂₀FN₃O₄S
Molecular Weight:393.439
Hs Code.:

Synonyms:2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole

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Chemical Property of 2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole

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Technology Process of 2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole

There total 4 articles about 2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1196104-05-8
3-tert-butyl-isoxazole-5-carbonyl chloride

: 1196104-10-5
2-(4-fluoro-benzenesulfonyl)-2-methyl-propionic acid hydrazide

: 1196103-48-6
2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole

Guidance literature:: With trichlorophosphate; at 100 ℃; for 3h; Sealed tube;

Reference yield:

: 630-19-3
pivalaldehyde

: 1196103-48-6
2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / water; tert-butyl alcohol / 0.5 h / 20 °C

1.2: 2 h / Reflux

2.1: potassium trimethylsilonate / tetrahydrofuran / 16 h / 20 °C

2.2: pH 1

3.1: thionyl chloride / N,N-dimethyl-formamide / Dichlorofluoromethane / 16 h / 20 °C

3.2: pH 1

4.1: trichlorophosphate / 3 h / 100 °C

With thionyl chloride; hydroxylamine hydrochloride; potassium trimethylsilonate; sodium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; Dichlorofluoromethane; water; tert-butyl alcohol;

Reference yield:

: 133674-39-2
3-tert-butylisoxazole-5-carboxylic acid methyl ester

: 1196103-48-6
2-(3-tert-butyl-isoxazol-5-yl)-5-[1-(4-fluoro-benzenesulfonyl)-1-methyl-ethyl]-[1,3,4]oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium trimethylsilonate / tetrahydrofuran / 16 h / 20 °C

1.2: pH 1

2.1: thionyl chloride / N,N-dimethyl-formamide / Dichlorofluoromethane / 16 h / 20 °C

2.2: pH 1

3.1: trichlorophosphate / 3 h / 100 °C

With thionyl chloride; potassium trimethylsilonate; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; Dichlorofluoromethane;