C₂₃H₂₃FN₂O₄S

Base Information

• Chemical Name: C₂₃H₂₃FN₂O₄S
• CAS No.: 1374229-67-0
• Molecular Formula: C₂₃H₂₃FN₂O₄S
• Molecular Weight: 442.511
• Mol file: 1374229-67-0.mol

Synonyms:C₂₃H₂₃FN₂O₄S

Chemical Property of C₂₃H₂₃FN₂O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₃FN₂O₄S

There total 23 articles about C₂₃H₂₃FN₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

C22H20FNO5S (1374233-32-5) + methylamine (74-89-5) → C23H23FN2O4S (1374229-67-0)

Guidance literature:

C₂₂H₂₀FNO₅S; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methylamine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 18.0%

C22H20FNO5S (1374233-32-5) + methylamine hydrochloride (593-51-1) → C23H23FN2O4S (1374229-67-0)

Guidance literature:

C₂₂H₂₀FNO₅S; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Product distribution / selectivity;

Reference yield:

ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate (691857-07-5) → C23H23FN2O4S (1374229-67-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

4.1: boron trichloride / dichloromethane / 0.5 h / -30 - -20 °C

4.2: Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0.33 h / 0 °C

6.1: triethylamine; lithium chloride / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 75 °C

7.2: 20 °C / pH 5 - 6

8.1: diethylzinc / 1,2-dichloro-ethane; toluene / -78 - -15 °C / Inert atmosphere

8.2: -78 - 20 °C

8.3: 2 h / 70 °C

9.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

9.2: 0.33 h / 20 °C

With water; hydrogen; diethylzinc; boron trichloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium chloride; lithium hydroxide; dmap; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

C₂₂H₂₀FNO₅S

methylamine hydrochloride

methylamine

2-bromo-5-methoxyaniline