1-(2,4-dimethoxyphenyl)-N-methylmethanamine

Base Information

• Chemical Name: 1-(2,4-dimethoxyphenyl)-N-methylmethanamine
• CAS No.: 102503-23-1
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Hs Code.: 2922299090
• European Community (EC) Number: 815-506-4
• DSSTox Substance ID: DTXSID90368580
• Wikidata: Q82155234
• Mol file: 102503-23-1.mol

Synonyms:102503-23-1;1-(2,4-dimethoxyphenyl)-N-methylmethanamine;N-(2,4-Dimethoxybenzyl)-N-methylamine;N-methyl-2,4-dimethoxybenzylamine;[(2,4-dimethoxyphenyl)methyl](methyl)amine;2,4-Dimethoxy-N-methylbenzylamine;MFCD04633426;(2,4-dimethoxy-benzyl)-methyl-amine;[2,4-dimethoxy-benzyl)-methyl-amine;(2,4-Dimethoxybenzyl)methylamine;SCHEMBL680457;DTXSID90368580;ULVUWTHGZHDWMW-UHFFFAOYSA-N;AMY41572;N-Methyl(2,4-dimethoxybenzyl)amine;STL255369;AKOS000263996;AB86566;CS-W006302;2,4-Dimethoxy-n-methylbenzenemethanamine;BS-13733;SY045940;Benzenemethanamine, 2,4-dimethoxy-N-methyl-;FT-0650937;EN300-07495;AB01000536-01;J-507235;Z56957486;F2169-1253

Chemical Property of 1-(2,4-dimethoxyphenyl)-N-methylmethanamine

Chemical Property:

• Vapor Pressure: 0.0111mmHg at 25°C
• Refractive Index: 1.5
• Boiling Point: 262.1 °C at 760 mmHg
• PKA: 9.32±0.10(Predicted)
• Flash Point: 104.6 °C
• PSA: 30.49000
• Density: 1.012 g/cm³
• LogP: 1.81410
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 181.110278721
• Heavy Atom Count: 13
• Complexity: 141

Purity/Quality:

98%min ^*data from raw suppliers

1-(2,4-Dimethoxyphenyl)-N-methylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1=C(C=C(C=C1)OC)OC

Technology Process of 1-(2,4-dimethoxyphenyl)-N-methylmethanamine

There total 5 articles about 1-(2,4-dimethoxyphenyl)-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-Dimethoxybenzaldehyde (613-45-6) + methylamine (74-89-5) → 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (102503-23-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 2h;

DOI:10.3390/molecules25061423

Reference yield: 5.0%

N,N-dimethyl(methylene)ammonium chloride (30354-18-8) + 1,3-Dimethoxybenzene (151-10-0) → 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (102503-23-1)

Guidance literature:

Product distribution; Ambient temperature;

DOI:10.1016/S0040-4039(00)97589-0

Reference yield:

N-(2,4-dimethoxybenzyl)formamide (84572-02-1) → 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (102503-23-1)

Guidance literature:

N-(2,4-dimethoxybenzyl)formamide; With lithium aluminium tetrahydride; In diethyl ether; at -78 - 20 ℃;

With sodium hydroxide; In diethyl ether; water;

upstream raw materials:

N,N-dimethyl(methylene)ammonium chloride

1,3-Dimethoxybenzene

2,4-Dimethoxybenzaldehyde

methylamine

Downstream raw materials:

N-(2,4-dimethoxybenzyl)-N-methyl-3-phenylprop-2-yn-1-amine

1-(2,4-dimethoxyphenyl)-N-({4-fluoro-5-[2-(trifluoromethyl)pyridin-3-yl]-1H-pyrrol-3-yl}methyl)-N-methylmethanamine

1-[5-(2-chloropyridin-3-yl)-4-fluoro-1H-pyrrol-3-yl]-N-(2,4-dimethoxybenzyl)-N-methylmethanamine

4-[(2,4-dimethoxy-benzyl)-methyl-amino]-2-fluoro-N-thiazol-2-yl-benzenesulfonamide

Refernces

• 1、 -. "PEPTIDOMIMETIC N5-METHYL-N2-(NONANOYL-L-LEUCYL)-L-GLUTAMINATE DERIVATIVES, TRIAZASPIRO[4.14]NONADECANE DERIVATIVES AND SIMILAR COMPOUNDS AS INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION". Paragraph 00215; 00246. . Retrieved 2021/09/26.
• 2、 Reuillon, Tristan,Bertoli, Annalisa,Griffin, Roger J.,Miller, Duncan C.,Golding, Bernard T.. "Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups". supporting information. p. 7610 - 7617. Retrieved 2012/10/29.